Edorium Journal of

Hematology

 
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Original Article
 
Overt increase in lupus anticoagulant level in HIV patients co-infected with pulmonary Mycobacterium tuberculosis infection: A prospective cohort study
Obi Simon Osita1, Amilo Grace Ifeoma2, Ifeanyichukwu Martin Ositadinma3, Ejeatulu Obi4, Balla Akawu5, Ngwu Amauche Martina6
1PhD, Department of Medical Lab. Science, University of Maiduguri, Nigeria.
2PhD, Department of Hematology, Faculty of Medicine, Nnamdi Azikiwe University Awka, Nigeria.
3PhD, Department of Immunology, Faculty of Medicine, Nnamdi Azikiwe University Awka, Nigeria.
4PhD, Department of Pharmacology Faculty of Medicine, Nnamdi Azikiwe University Awka, Nigeria.
5MSc, Department of Medicine/HIV Clinic University of Maiduguri, Nigeria.
6MSc, Department of Hematology and Immunology, Enugu State University of Science and Technology, Enugu, Enugu State, Nigeria.

Article ID: 100001H05OO2015
doi:10.5348/H05-2015-1-OA-1

Address correspondence to:
Ifeanyichukwu Martin Ositadinma
Immunology Department
College of Health Sciences, Nnamdi Azikiwe University
Nnewi Campus, PMB 5001, Nnewi
Nigeria
Phone: +234 08037200407

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How to cite this article
Osita OS, Ifeoma AG, Ositadinma IM, Obi E, Akawu B, Martina NA. Overt increase in lupus anticoagulant level in HIV patients co-infected with pulmonary Mycobacterium tuberculosis infection: A prospective cohort study. Edorium J Hematol 2015;1:1–6.


Abstract
Aims: Lupus anticoagulant (LA), an antiphospholipid antibody is known to be associated with autoimmune conditions, acute opportunistic infection and viremic challenges. It is now, however, considered as an important risk factor for otherwise inexplicable thrombosis as is seen in HIV infected individual in the recent times. To assess the plasma level of LA in HIV individuals co-infected with pulmonary tuberculosis (PTB).
Methods: After obtaining informed consent from the participants and ethical approval from University of Maiduguri Teaching Hospital Ethics committee, two hundred and fifty HIV positive subjects were tested for the presence of LA by dilute Russell's viper venom time (DRVVT). Sputum acid-fast bacilli and Mycobacterium tuberculosis IgM antibody were tested by Ziehl-Neelsen and immunochromatographic methods, respectively. Lupus anticoagulant was investigated with reagent kits acquired from Siemens Health Care Diagnostic Products, Germany. Apparently Health, HIV sero-negative subjects (251) served as control. The study was conducted between June 2011 and September 2013.
Results: The mean ratio of LA was significantly increased in HIV positive subjects and overtly increased in HIV/PTB subjects compared to the control subjects (p<0.001).
Conclusion: HIV infection induces the presence of LA; and HIV/PTB co-morbidity worsen this condition. The presence of LA is considered in the recent time as a risk factor for thrombotic events.

Keywords: HIV, Lupus anticoagulant, Mycobacterium tuberculosis, Pneumocystis carinii, Pulmonary tuberculosis co-infection, Ziehl-Neelsen stain

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Author Contributions:
Obi Simon Osita – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Amilo Grace Ifeoma – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Ifeanyichukwu Martin Ositadinma – Conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Ejeatulu Obi – Acquisition of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Balla Akawu – Acquisition of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Ngwu Amauche Martina – Acquisition of data, Drafting the article, Critical revision of the article, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2015 Obi Simon Osita et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.



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